Renal dysfunction can activate the renin-angiotensin-aldosterone system, cause oxidative stress, and increase the synthesis of endothelin and inflammatory factors,often combined with a variety of risk factors such as old age, obesity, smoking history, hypertension, diabetes, dyslipidemia, and hyperuricemia, which leads to endothelial dysfunction and promotes atherosclerosis [11]. The gene discussed is REN; the disease is Hypertension.