We believe that our prediction model can be further improved by combined analysis of DTI and DSC-PWI data both from contrast enhancing and peritumoral regions of neoplasms along with incorporation of molecular information such as MGMT promoter methylation and/or isocitrate dehydrogenase (IDH) mutational status into the multivariate regression analysis in the future studies. The gene discussed is IDH3A; the disease is neoplasm.