By comparing the expression of 91 ARGs in the tumor group and normal group, we showed that CAPN14, EGFR, YWHAQ, MAP2K1 were prognostic predictors of BLCA by univariate Cox regression analysis, and high expression of EGFR, YWHAQ, MAP2K1 were associated with poor prognosis of BLCA, low expression of CAPN14 was associated with poor prognosis of BLCA. The gene discussed is EGFR; the disease is bladder transitional cell carcinoma.