Then, we applied GO and KEGG, which showed that ARGs.cluster.B was significantly enriched in immune-related pathways (T cell activation, T cell migration, T cell apoptotic process, MHC protein binding, and cytokine-cytokine receptor interaction) and cancer-related pathways (DNA replication, cell growth, apoptosis, and PI3K-Akt signaling pathway) (Fig. 3C, D), suggesting that ARGs.cluster.B may play an important role in tumor development and immune regulation. This evidence concerns the gene HLA-C and cancer.