The meta-analysis of MR results confirmed that higher BMI (OR = 1.0016, p = 0.009), waist circumference (OR = 1.0073, p = 0.007), adiponectin (OR = 1.0026, p = 0.004), triglycerides (OR = 1.0015, p = 0.008) and body fat percentage (OR = 1.0104, p = 0.006) could increase the risk of urolithiasis. The gene discussed is ADIPOQ; the disease is urolithiasis.