These observations suggest that evaluation for NAFLD should be considered at diagnosis in all subjects with hemochromatosis and HFE p.C282Y/p.C282Y, regardless of ALT and AST levels, although current guidelines for hemochromatosis diagnosis and management do not recommend evaluation for NAFLD in all patients with or suspected to have hemochromatosis [19]. The gene discussed is GPT; the disease is hemochromatosis.