We confirmed that the correlation between ACAG concentration and 30 d all-cause death was nonlinear (Fig. 2) after adjusting for age, sex, ethnicity, weight, atrial fibrillation, hyperlipidaemia, Charlson Comorbidity Index, mechanical ventilation requirement, heart rate, SBP, DBP, SPO2, creatinine, glucose, sodium, potassium, platelets, WBC, RBC, Hb, ALT, CK-MB, hypertension, stroke, bleeding, vasoactive drugs use, β-blockers use, Troponin-T, CABG, and PCI. This evidence concerns the gene GSTM1 and stroke disorder.