We confirmed that the correlation between ACAG concentration and 30 d all-cause death was nonlinear (Fig. 2) after adjusting for age, sex, ethnicity, weight, atrial fibrillation, hyperlipidaemia, Charlson Comorbidity Index, mechanical ventilation requirement, heart rate, SBP, DBP, SPO2, creatinine, glucose, sodium, potassium, platelets, WBC, RBC, Hb, ALT, CK-MB, hypertension, stroke, bleeding, vasoactive drugs use, β-blockers use, Troponin-T, CABG, and PCI. The gene discussed is GSTM1; the disease is Hypertension.