To determine whether microglial markers were associated with longitudinal accumulation of amyloid and/or tau as well as cognitive decline, we tested separate linear mixed effect models using global amyloid-PET, three composite tau-PET regions (that is, for Braak stages I–II, Braak stages III–IV and Braak stages V–VI) and Mini-Mental State Examination (MMSE) scores as the outcomes, and the interactions between the microglial markers and time as predictors, while adjusting for age, sex, presence of cognitive impairment and years of education (for models including cognition). The gene discussed is MAPT; the disease is Cognitive impairment.