However, none of these enrichments was found in the old group, but pathways related to cell migration (cell adhesion molecules and focal adhesion), immunodeficiency and IgA production were found, suggesting the potential disability of processing the viral proteins from the vaccine and presenting them as peptide antigens by the lymphocytes of the old donors (Fig. 6d,e and Supplementary Table 4). This evidence concerns the gene CD79A and Immunodeficiency.