APOE and Alzheimer disease: We found a negative correlation between the effects of the rs1921622 A allele and the effects of CSF sST2 level on modulating microglial gene expression in female APOE-ε4 carriers with AD (R2 = 0.860, P < 0.0001; Extended Data Fig. 8), supporting the notion that the variant exerts its modulatory effects on microglia through the regulation of CSF sST2 level.