Interestingly, both the MR analysis of sST2 and the meta-analysis of rs1921622 showed that the associations between AD risk and sST2/rs1921622 in female APOE-ε4 carriers are stronger in the Chinese population than those in the European-descent populations (Chinese versus European descent, P = 5.55 × 10−4 and 0.017 for the MR analysis of sST2 and meta-analysis of rs1921622, respectively; Fig. 4a–c and Supplementary Tables 6–8), suggesting an ethnic-specific effect of sST2/rs1921622 in modulating AD risk. This evidence concerns the gene APOE and Alzheimer disease.