Moreover, plasma sST2 level was positively associated with the AD-related endophenotypes we examined—namely, the decreased volumes of gray matter (β = −0.695, FDR = 0.003; Fig. 1b) and increased levels of plasma biomarkers corresponding to AD (that is, P-tau181 (ref. 33), β = 0.413, FDR = 0.005; Fig. 1c) and neurodegeneration (that is, neurofilament light polypeptide (NfL)34, β = 0.107, FDR = 0.004; Fig. 1d). Here, NEFL is linked to Alzheimer disease.