APOE and Alzheimer disease: The results show that while sST2 level was not associated with AD risk in all individuals (Chinese, β = −0.023, FDR = 0.861; European descent, β = 0.077, FDR = 0.131; Fig. 4a and Supplementary Table 6), increased sST2 level was associated with increased AD risk in female APOE-ε4 carriers in both Chinese and European-descent populations (Chinese, β = 0.772, FDR = 1.70 × 10−5; European-descent, β = 0.168, FDR = 0.023; Fig. 4a,b and Supplementary Table 6).