Among individuals with AD, specifically in females, the APOE-ε4 carriers exhibited greater Aβ deposition in the frontal cortex than that in the APOE-ε4 noncarriers (females, β = 1.967, P < 0.05; males, β = −0.621, P = 0.422; Extended Data Fig. 7a,b). Here, APOE is linked to Alzheimer disease.