APOE and Alzheimer disease: Consistent with its AD-protective effects (Supplementary Table 9), the rs1921622 A allele was associated with delayed onset age of dementia (hazard ratio (HR) = 0.874, FDR = 0.011; Fig. 5a), better cognitive scores (β = 1.622, FDR = 0.001; Fig. 5b) and larger entorhinal cortex volumes (β = 0.214, FDR = 0.027; Fig. 5c) in female APOE-ε4 carriers.