APOE and Alzheimer disease: Fourth, given our finding that the rs1921622 A allele is a common AD-associated variant, manipulations of sST2 by targeting this genetic variant could be developed for specific subgroups of individuals who have high sST2 levels (for example, female individuals who carry APOE-ε4 but not the rs1921622 A allele, accounting for 6.2–12.2% of individuals with AD), enabling patient stratification and precision medicine.