Meanwhile, endothelial expression of sST2 can be downregulated by the rs1921622 A allele, a genetic variant that exerts an AD-protective effect specifically in female APOE-ε4 carriers, a subgroup of people accounting for 24.3–33.6% and 32.5–50.4% of individuals with AD in Chinese and European-descent populations, respectively (Supplementary Tables 1 and 5). This evidence concerns the gene APOE and Alzheimer disease.