TREM2 and amyloidosis: For example, soluble TREM2 protein (sTREM2) level is increased in the cerebrospinal fluid (CSF) of individuals with AD12–14, and injection of sTREM2 in transgenic mouse models of amyloidosis alleviates Aβ accumulation by enhancing the interaction between microglia and Aβ and subsequent Aβ phagocytosis15,16.