In contrast, female APOE-ε4 carriers with AD who co-harbored the rs1921622 A allele showed increased colocalization between Iba-1+ microglia and Aβ plaques (β = 2.017, P < 0.05; Fig. 6c,d and Extended Data Fig. 7f,g). The gene discussed is APOE; the disease is Alzheimer disease.