Older age, male sex, and abnormal laboratory parameters at admission, including increased WBC count, decreased neutrophils and lymphocytic count, increased MCV, abnormal levels of BUN, Cr, total and direct bilirubin, Log CK-MB, LDH, Troponin, CRP, potassium (K), and creatinine phosphokinase (CPK) significantly associated with the reduced survival of COVID-19 patients (p-value < 0.05). This evidence concerns the gene PIK3C2A and COVID-19.