Using the Liver Hepatocellular Carcinoma (LIHC) TCGA RNA-seq database, we determined the association between survival and mRNA expression of ANXA1, ANXA2, and ANXA5 to validate their prognostic relevance in liver cancer, as well as that of PTGR1, GSTP1, two well-known liver tumor markers, and alpha-fetoprotein (AFP), widely used as a marker for the diagnosis of liver cancer in clinical practice28, to validate its potential prognostic relevance in liver cancer (Fig. 6). This evidence concerns the gene ANXA2 and liver cancer.