Inspection of these breakpoints in the UCSC Genome Browser (Table 1; Fig. 2) revealed disruption of the COL4A2 gene by the translocation carrier 46, XY, t(13; 16)(q34; q12.1) chromosome 13 breakpoint in case 1, which encodes a protein important for angiogenesis and tumor growth suppressors, and the chromosome 16 breakpoint does not involve a functional gene. Here, COL4A2 is linked to neoplasm.