To analyze the expression profiles of CD44 in the pan-cancer dataset, a comparative analysis of CD44 expression was performed between cancer and control samples using the TCGA database, the CD44 levels were significantly up-regulated in CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, READ, and THCA, whereas it was downregulated in LUAD, PRAD, and UCEC (Fig. 1). Here, CD44 is linked to cancer.