RNF31 expression was related to different immune subtypes in BLCA, BRCA, CESC, COAD, ESCA, HNSC, kidney renal clear cell carcinoma (KIRC), LIHC, LUAD, mesothelioma (MESO), ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), pheochromocytoma and paraganglioma (PCPG), PRAD, READ, sarcoma (SARC), skin cutaneous melanoma (SKCM), STAD, testicular germ cell tumors (TGCT), THCA, UCEC and uterine carcinosarcoma (UCS). The gene discussed is RNF31; the disease is cutaneous melanoma.