Considering that sPD-L1 showed potential prognostic value for advanced GC and that exoPD-L1 might be associated with the host immunosuppressive status, further research into the prognostic and predictive value of both sPD-L1 and exoPD-L1 for patients with GC receiving PD-1 inhibitors alone or in combination with cytotoxic chemotherapy is required. Here, SPDL1 is linked to gastric cancer.