Compared to Mincleflox/flox/Lyz-cre−/− control littermate mice immunofluorescence confirmed the deletion of Mincle-expressing macrophages in the skin lesions and the significant improvement in the severity of psoriasis in Mincleflox/flox/Lyz-cre+/+ mice with a few Mincle + /F4/80+ macrophages (Fig. 4A–C, E). Here, CLEC4E is linked to psoriasis.