Real-time PCR results further confirmed that the mRNA levels of psoriasis-related factors keratin-17, integrin β1, and CXCL9, as well as the mRNA levels of inflammation-related factors IL-1β, IL-6, TNF-α and iNOS, were strongly inhibited in skin of Mincleflox/flox/Lyz-cre+/+ mice (Fig. 4H). The gene discussed is TNF; the disease is psoriasis.