Adoptive transfer with Tomato-expressing BMDMs restored Mincle-expressing macrophage infiltration and inflammatory responses as demonstrated by upregulation of pro-inflammatory cytokines (IL-1β and IL-6) (Fig. 3E, F), Mincle and iNOS (Fig. 3G, H), resulting in the development of severe skin lesion in psoriasis mice (Fig. 3C). The gene discussed is IL1B; the disease is psoriasis.