CLEC4E and psoriasis: In this present study, we detected the expression pattern of Mincle in the skin of psoriasis patients and mouse models, and explored the promotion of Mincle on psoriasis inflammation and damage by knocking out Mincle in macrophage, and used Mincle neutralizing antibody to develop a novel therapeutic target and drug for psoriasis, providing new direction and option for the clinical treatment of disease.