CLEC4E and psoriasis: It was also found that the M1 macrophage marker iNOS was significantly increased in psoriasis by flow cytometry, and the expression of iNOS was significantly reduced both in vivo and in vitro when Mincle was knocked out, indicating that Mincle maintained the M1 polarization of epidermal macrophage and promoted the inflammatory response and skin damage associated with its downstream signaling Syk and NF-κB in psoriasis.