Furthermore, even in wild-type mice, deletion of any one of the tumor suppressor genes Pax5, Sfpi1, Ikzf1, Pten or Cdkn2a has been reported specifically in irradiated animals in copy number analyses of lymphomas, acute myeloid leukemia and thymic lymphoma [35, 45, 46]. Here, SPI1 is linked to acute myeloid leukemia.