MKI67 and neoplasm: It is reported that patients with high Ki67 and E-cadherin positive rate had faster tumor growth, worse tissue differentiation and worse prognosis.32, 33, 34 The results of IHC experiments found that miRNA-29a-3p was significantly negatively correlated with the expression of Ki67 and E-cadherin (p < 0.05), that is, the high expression of miRNA-29a-3p inhibited the proliferation, invasion and metastasis of HPC cells.