RBM46 and Infertility: For instance, RBP Rbm46 knockout mice had reduced testes size and spermatogenetic defect and thus were infertile [11]; Boule was able to bind to a tremendous amount of spermatogenesis-related mRNAs and was involved in the spermatogenetic process in mice testes through forming amyloid-like aggregation both in vivo and in vitro [12]; The loss of RBP Tulp2 led to infertility in male mice by reducing the quantity and quality of sperms [13].