The intrinsic B cell TLR5-BCR linked coengagement mechanism would not only effectively induce production of specific antibodies at early stages of Salmonella infection when T cell help is not yet available but would also potentiate the antibody response at later stages when T cell help becomes available, as exemplified by an accurate comparison of the anti-flagellin antibody response in C57BL/6 andTcrβ−/−Tcrδ−/− mice. This evidence concerns the gene TLR5 and Salmonella Infections.