In addition, measurement of tumor-infiltrating lymphocytes revealed a significant increase in the population of T cells (Cd3+Cd45+), especially CD8+ T (Cd8+Cd3+Cd45+), in the TME of B16-F10 tumors from Irg1−/− mice compared with Irg1+/+ controls (Fig. 2E). The gene discussed is CD8A; the disease is neoplasm.