PDX1 and neoplasm: Furthermore, pancreatic cancer cells derived from the genetically engineered mouse tumor model (LSL-KrasG12D; LSL-Trp53R172H; Pdx1-Cre mice; KPC) were implanted into the pancreas of Irg1−/− and Irg1+/+ mice, and the KPC tumor growth was also remarkably inhibited in Irg1−/− mice as monitored by bioluminescent imaging (Fig. 1C).