As a result, the infusion of Irg1−/− macrophages suppressed the growth of KPC tumors at both early (10 days after inoculation) and later stages (21 days after inoculation), resulting in a 58.8 and 50.0% decrease in tumor weight, respectively, as compared to those receiving Irg1+/+ macrophages (Fig. 7, G and H). Here, ACOD1 is linked to neoplasm.