We found that the growth of B16-F10 tumor in Irg1−/− mice (without PD-L1 blockade) was reduced to the extent achieved by the anti–PD-L1 in Irg1+/+ mice, extending the life span from 14 days in untreated Irg1+/+ mice to 18 days in Irg1−/− mice or Irg1+/+ mice treated with PD-L1 antibody (Fig. 5, A and B). The gene discussed is CD274; the disease is neoplasm.