ACOD1 and neoplasm: Of note, Irg1 mRNA expression in wild-type BMDMs was induced at 6 hours after coculture with B16-F10 tumor cells, and higher mRNA expression of proinflammatory genes and those involved in antigen presentation and chemotaxis was observed in Irg1−/− BMDMs at 12 hours after B16-F10 coculture (Fig. 3E).