Furthermore, 5hmC mapping showed that its enrichment at the promoter regions of chemokine genes (e.g., Cxcl9, Cxcl10, Ccl2, Ccl3, Ccl4, and Ccl5) was increased in TAMs from Irg1−/− tumor-bearing mice than Irg1+/+ controls (Fig. 4B and fig. Here, ACOD1 is linked to neoplasm.