FGL1 and hepatocellular carcinoma: Moreover, FGL1 protein levels were reduced in both 293T and HCC cell lines with aspirin treatment (Figure 4, F and G, and Supplemental Figure 4, C and D), which could be partially rescued by the proteasome inhibitor MG132 (Figure 4H), implying that aspirin induced the degradation of FGL1 via the ubiquitin-proteasome pathway.