CD8A and neoplasm: We next examined the level of tumor-infiltrating lymphocytes (TILs) using IHC staining and discovered that AGK2 treatment alone increased the tumor-infiltrating CD8+ T cell population and granzyme B levels, and, consistently, the combination of AGK2 and PD-L1 blockade had a significant, synergetic effect on the stimulation of tumor infiltration of CD8+ T cells and antitumor immunity (Figure 3, F and G, and Supplemental Figure 3, J and K).