Early-life exposure to POPs has also been linked to hyperglycemia (Baumert et al., 2022), increased metabolic syndrome (Warner et al., 2014; 2017), hypoinsulinemia (Jensen et al., 2014; Park et al., 2016), reduced HOMA-β (Jensen et al., 2014; Park et al., 2016), and higher non-fasted insulin levels (Tang-Péronard et al., 2015) in children. This evidence concerns the gene INS and Hypoinsulinemia.