We also varied the HSCL parameters, taking into account several studies suggesting that CML stem cells are at least 5–10 times less sensitive to CCL3-mediated inhibition of self-renewal (Eaves et al., 1993, Chasty et al., 1995; Wark et al., 1998; Dürig et al., 1999); for example, γ1Lγ1 should be less than 0.2. The gene discussed is CCL3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.