We used our inducible Scl-tTA:TRE-BCR/ABL (BAtTA) mouse model of myeloproliferative neoplasm, which we previously characterized for HSPC remodeling and MPP3 expansion associated with leukemic GMP cluster formation and myeloid cell production (Reynaud et al., 2011; Hérault et al., 2017; Kang et al., 2020). The gene discussed is MPP3; the disease is myeloproliferative disorder.