TGFB1 and neoplasm: On the other hand, macrophages were polarized into M2-type by Th2 cytokines such as interleukin (IL)-4, IL-10, and IL-13 and produce anti-inflammatory cytokines such as IL-10 and transforming growth factor beta (TGF-β) to promote tumor development; these are considered pro-tumor or “bad” macrophages [8, 9].