Regarding the effect of ERT on the expression of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, De Francesco et al. [46] observed no significant difference in treated vs untreated FD patients, whereas other authors have reported a significant reduction in serum levels of pro-inflammatory cytokines and oxidative stress markers following agalsidase alfa therapy [68]. This evidence concerns the gene TNF and Fabry disease.