Moreover, they found the suppression of glial fate in MECP2 mutant NPCs (i.e., those from Rett syndrome iPSCs) is due to overexpression of LIN28, a RNA binding protein that had been previously shown to blocks the differentiation into glia and increases differentiation into neurons (Balzer et al. 2010). Here, MECP2 is linked to atypical Rett syndrome.