Genes involved in neuroplasticity, synaptic function (C1QBP, APP, NEFL, LRRN3, MEF2C, THY1), and neuron-microglia crosstalk (CD200 and IL34) were downregulated in NHD brains (Fig. 6a and Supplementary Table 6, online resource). The gene discussed is CD200; the disease is Nasu-Hakola disease.