This protein has been shown to be a potent inhibitor of tumor growth and angiogenesis.[15] Furthermore, it has been shown that TSP-2 in hUB-MSCs promotes the differentiation of chondroprogenitor cells to chondrocytes through paracrine effects.[16] After searching PubMed and web of science for relevant research articles from 1991 to 2022 using the keyword TSP-2 in combination with cartilage, we reviewed recent advances in the use of TSP-2 for cartilage regeneration and the mechanism of action, which is expected to provide new targets for clinical cartilage repair. This evidence concerns the gene THBS2 and neoplasm.