IL1A and colitis: A potent mediator of inflammation and immunological response, IL1A belongs to the interleukin 1 family and is synthesized by various cell types, including macrophages.[62] Evidence suggests that IL1A plays an important role in inflammatory diseases such as cardiovascular disease, colonic inflammation, neuroinflammation, and human skin inflammation.[63] Lukens et al found a critical role for IL1A in tissue damage and wound inflammation in the severe inflammatory syndrome of neutrophilic skin disease.[50]