Previous research has shown that immune cells that infiltrate tumors are an important regulator of tumor development and progression in GC.[31–33] We found that higher JAM3 expression was associated with increased infiltration of activated T cells, CD4 memory T cells, Macrophages M0, dendritic cells activated, mast cells activated, and neutrophiles and decreased infiltration of naive B cells, monocytes, Macrophages M2, resting dendritic cells, and resting mast cells. Here, CD4 is linked to neoplasm.