During tumor progression, JAM3 has been shown to play a vital role in controlling neoplasm growth.[11–13] In lung squamous cell carcinoma cell, overexpression of JAM3 has been demonstrated to restore tight junctions and an epithelial phenotype.[14] Even while JAM3 has been found to have a function in many different types of cancer, most studies have only revealed that it does so as a downstream pathway of other genes. This evidence concerns the gene JAM3 and squamous cell lung carcinoma.