Our results were consistent with those of Stefan, who reported that serum miR-191 and miR-337-3 were potential biomarkers in RCC.[39] Similarly, miR-296 was found to suppress tumor metastasis in colorectal cancer via S100A4.[40] At the same time, a previous study reported that miRNA-518 suppressed tumor cell growth and induced apoptosis in gastric cancer.[41] As a consequence, STAT2 can regulate tumor cell proliferation, invasion, and apoptosis via these miRNAs in KIRC. This evidence concerns the gene S100A4 and colorectal cancer.