STATs and the JAK-STAT pathway regulate cytokine associated inflammation and immunity in the tumor microenvironment.[6] Correlation between expression of STAT2, and immune cells, as well as biomarker sets in KIRC patients, revealed that there was a significant positive correlation between expression of STAT2 and immune cells such as B cells, CD8+ T cells, CD4+ T cells, macrophage, Neutrophils, and dendritic cells. This evidence concerns the gene CD8A and neoplasm.