DEAH-box helicase 33 (DHX33) is part of the DEAD/DEAH box protein family and has been discovered to be essential for several facets of RNA metabolism.[11] In previous studies, DHX33 has been defined as a key player in ribosome biogenesis and a cell membrane RNA sensor that activates the NLRP3 inflammasome.[12,13] The DHX33 protein was also found to be dysregulated in several cancers, including lymphoma, glioblastoma, liver cancer, and lung cancer.[14–17] So far, the immunological implication of DHX33 in sarcoma has not been examined and reported. This evidence concerns the gene DHX33 and cancer.