LMNA and Hutchinson-Gilford progeria syndrome: For example, this kind of regulation is central for the activities of LMNA gene that produces nuclear lamin A and nuclear lamin C by alternative splicing and whose 3ʹUTR are different; the differential binding of miRNAs to these 3ʹUTRs has been proposed to play a central role in the HGPS phenotype (23).