To evaluate resistance to chemotherapeutic drugs, we treated NOD/SCID mice injected with WT SIX2+CITED1+ cells with vincristine, commonly used clinically for WT.[33, 34, 35, 36] Standard vincristine dosing protocols for mice[36] did not delay or prevent tumor growth (Figure 2F), suggesting that WT SIX2+CITED1+ cells also manifest chemotherapy resistance. This evidence concerns the gene SIX2 and neoplasm.