CSCs are capable of self‐renewal, differentiation, and tumorigenicity in animal hosts and are defined by a specific set of criteria: small numbers of transplanted cells should generate a tumor in vivo, cells should be resistant to chemotherapeutics, and can be identified by specific markers reflecting the tumor of origin.[27, 28, 29, 30] WT SIX2+CITED1+ cells tumor formation capabilities were assessed through a series of in vivo experiments (Figure 2C and Figure S5, Supporting Information). Here, SIX2 is linked to neoplasm.