CDC42 and melanoma: In this study, we present that Cdc42(G12V) overexpression in A375 melanoma cell lines, which have a background BRAF mutation, increased proliferation, anchorage independent cell growth, cell migration, and invasion, compared to the parent cell line Treatment of A375 cells expressing Cdc42(G12V) with PI3K inhibitor significantly inhibited proliferation, anchorage-independent cell growth, migration, and invasion in these cells compared to A375 parent cells, showing that PI3K is essential for Cdc42 activity in this context.