We found that cytokine IL-4, IL-12P70, IL-1β, and IL-22 in noninfected CML patients is higher than that of healthy people (Table 3, Supplementary Figure 1(A)–1(C) and 1(I)), but IL-5, IFN-γ, TNF-α, TNF-β, and IL-17F is lower than the normal population (Table 3, Figures 2(c) and 2(e), Supplementary figure 1(E), 1(F) and 1(H)). The gene discussed is IL1B; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.