KDR is upregulated in the tumor vasculature of anaplastic oligodendrogliomas, glioblastoma multiforme, and ependymomas with necrosis, whereas oligodendroglioma, grade II astrocytomas, and anaplastic astrocytomas tend to express weak-to-nondetectable signals [28]. This evidence concerns the gene KDR and astrocytoma (excluding glioblastoma).