KDR and brain ischemia: Gastrodiol components increased the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), α-SMA, and Smad-3 and reduce the expression of Ang-2 in the brain of middle cerebral artery occlusion/reper-fusion (MCAO/R) rats and promoted angiogenesis and maturation after cerebral ischemia [89].