In this study, the analysis of immunohistochemical results revealed that the expression of BRCA1 is similar in CNC and BLBC, and the targeted therapeutics to BRCA1 may also have beneficial potential in CNC; the expression of HIF-1α in CNC is significantly higher than that of BLBC, which may serve as novel entry points to distinguish between CNC and BLBC. The gene discussed is BRCA1; the disease is Carney complex.