To address the possibility that a resiquimod-induced autocrine IFN-loop sustains IL10 transcription and translation, IL-10 levels in culture supernatants were measured 48 h after activating CLL cells with resiquimod (S) or resiquimod and IL-2 (2S) in the presence or absence of the IFNAR antibody anifrolumab (18). This evidence concerns the gene IFNA1 and B-cell chronic lymphocytic leukemia.