IL10 mRNA expression was increased in CLL cells exposed to ruxolitinib in vivo (Figure 1B) and expression of core enrichment genes including CD83 and SOCS3 for the “Hallmark_TNFA_Signaling_via_NFκB” data set (23, 24) is shown in Supplementary Figure 1A. Here, SOCS3 is linked to B-cell chronic lymphocytic leukemia.