We found that IL-22-/- mice receiving B. fragilis were more sensitive to DSS-induced colitis than wild-type (IL-22+/+) mice receiving B. fragilis, evidenced by more weight loss (Figure 5A), a higher DAI score (Figure 5B), a shorter colon length (Figures 5C, D) and a higher HAI (Figures 5E, F; Figure S6). The gene discussed is IL22; the disease is colitis.