Of all significant HLA alleles and haplotypes, notably, only HLA-DQB1*04:01 and HLA-DPB1*05:01 allele frequencies were significantly increased in patients with ICI-T1DM compared with ICI-controls after Bonferroni correction (Pc=0.033 and Pc=0.04, respectively) (Tables 2B, 2C). Here, HLA-DPB1 is linked to type 1 diabetes mellitus.