Leu (L) > Pro (P) at position 56 (Figure 2A), E > G at position 70 (Figure 2B), Ile (I) > V at position 203 (Figure 2C), and Leu-Gln-Leu-Thr-Thr-Gln-Asn-His-His (L-Q-L-T-T-Q-N-H-H) > Gln-Glu-Val-Gly-Ala-Gln-Ser-Arg-Gln (Q-E-V-G-A-Q-S-R-Q) at positions 53-84-85-89-140-181-182-220-221 of HLA-DQβ1 in ICI-T1DM (Figure 2D). This evidence concerns the gene HLA-DQB1 and type 1 diabetes mellitus.