Notably, patients with ICI-T1DM in Japan have been reported to have HLA-DRB1*11:01/*13:02 (23), DRB1*04:05 (24–26), DRB1*04:06 (26), and DRB1*09:01 (25), and all of patients above had G86 at HLA-DRβ1. This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.