Allele frequencies of HLA-DRB1*04:05 (Table 2A) and HLA-DQB1*04:01 (Table 2B), both alleles in complete linkage disequilibrium, were significantly higher in patients with ICI-T1DM than in general controls and also in ICI-controls. This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.