Based on the conditional multiple regression analysis, in addition to HLA-DPB1*05:01 allele, alleles of HLA-DRB1*04:05 and DQB1*04:01, and HLA-DRB1*04:05-DQB1*04:01 haplotype were found to be susceptible to ICI-T1DM (Tables 2A–E) . This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.