Regarding HLA-DQβ1, amino acids carriages at amino acid positions 56, 70, 203, and 53-84-85-89-140-181-182-220-221 (each amino acid in complete linkage disequilibrium) of HLA-DQβ1 were significantly different between the patients with ICI-T1DM and ICI-controls (Supplementary Tables 5A, B). This evidence concerns the gene HLA-DQB1 and type 1 diabetes mellitus.