Further, univariate logistic regression analysis was thoroughly performed to examine relationships between ICI-T1DM and amino acid polymorphisms at HLA-DRβ1 (237 amino acid positions) (Supplementary Table 3A), DQβ1 (237 amino acid positions) (Supplementary Table 3B, and DPβ1 (229 amino acid positions) (Supplementary Table 3C). This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.