After Bonferroni correction for all significant amino acid polymorphisms, β57 at HLA-DRβ1 (Pc=0.046 by Bonferroni correction, shown with #) (Figure 1B), and β205 at HLA-DPβ1 were significantly increased in patients with ICI-T1DM compared with ICI-controls (Pc=0.011 by Bonferroni correction, shown with #) (Figure 3C). The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.