HLA-DRB1*04:05-DQB1*04:01-DPB1*05:01 haplotype frequency was significantly higher in patients with ICI-T1DM than those of general controls and also in ICI-controls (P=0.006 and 0.002, respectively) (Table 2E). The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.