They showed that allogeneic T and NK cells infiltrated cell line-derived spheroids, inducing immune-mediated cancer cell killing and 3D structure destruction via the engagement of the activating receptor NKG2D (100) while cancer cells tried to evade immune recognition by upregulating HLA-E, ligand of the inhibitory receptor NKG2A expressed by CD8 T and NK cells. The gene discussed is HLA-E; the disease is cancer.