In our study, eight amino-related lncRNAs associated with glioma prognosis by bioinformatics analysis were found, namely, AL357060.1, HOXA-AS3, LINC01561, Z95115.1, AL353796.1, LEF1-AS1, AC005224.3, and TMEM220-AS1, which had significant differences in the expression in normal brain and glioma tissue. The gene discussed is LEF1; the disease is central nervous system cancer.