CHDH and coronary artery disorder: Although the discovery of disease gene mutations' penetrance is well known, this research has yielded three noteworthy insights: first, human CHD mutations affect a heterogeneous set of molecules that orchestrate cardiac development; second, CHD mutations frequently alter gene-protein dosage; and third identical pathogenic CHD mutations cause a variety of distinct malformations, and this suggests that higher-order interactions are responsible for specific CHD phenotypes.