Further validation of the diagnostic value was performed using ROC curves in the GSE30528 and GSE30529 datasets, and finally, some important hub genes such as TYROBP, ITGB2, CD53, IL10RA, LAPTM5, CD48, C1QA, and IRF8 were associated with a risk for DN, suggesting that these may play an important role in the mechanisms of DN onset and progression. This evidence concerns the gene IRF8 and liver dysplastic nodule.