Functional enrichment analysis revealed that the differential genes might be engaged in biologic processes as immune response, antigen-antibody activation, and complement activation, promoting the development of DN through phagocytosis vesicles, the PI3K-Akt signaling pathway, focal adhesion, the NIK/NF-kappaB signaling pathway, and the Rap1 signaling pathway. This evidence concerns the gene AKT1 and liver dysplastic nodule.