TYROBP was identified by bioinformatics analysis as a potential candidate gene for lupus nephritis (Zhang et al., 2020) and a candidate gene for tubulointerstitial fibrosis in diabetic nephropathy, possibly associated with the epithelial-mesenchymal transition of the renal tubular epithelium (Bai et al., 2023). Here, TYROBP is linked to diabetic kidney disease.