For the longest time, BCR-ABL1 fusion was believed to be a hallmark of CML patient samples, but recent studies have described a rare category of AML with BCR-ABL translocation (Kang et al., 2016; Neuendorff et al., 2016; Sampaio et al., 2021). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.