FH and neoplasm: For FH-negative mutation fibroids (in ULM7.1, ULM7.2, ULM7.3, ULM7.4 and ULM7.8) observed in this patient, the presence of other genetic mutations such as MED12 are still active in the subset of these fibroids, and the MED12 mutation alone can drive tumour formation (Table 1 and Figure 2).